15th IUTAM Summer School - Bone Cells and Tissue Mechanics
Invited Lecturers
- Stephen C. Cowin (City University of New York, New York, NY, USA)
1. Introduction, then some material on Collagen.
2. Bone tissue microstructure; bone blood supply and bone hydraulics.
4. The mechanosensory system in bone.
5. Bone remodeling theories, then cartilage if time permits.
6. Friday Q&A
7. Monday Q&A- John Currey (University of York, York, England, Great Britain)
1. ‘Form function relationships in whole bones’. E.g. Hollowness, straightness, expansion at ends, various roles of cancellous, sandwich bones.
2. ‘Composition-mechanical property relations in bone tissue’. Stress-strain curve and mechanical properties derived therefrom, Range of composition (mineral-organic-water) The various effects that mineral and porosity have on properties, difference between pre-yield and post-yield.
3. ‘Histology-mechanical property relations in bone tissue’. Hierarchical structure, lamellar, woven, fibrolamellar, secondary remodelling How they are produced and what they mean, mechanically.
4. ‘The role of microdamage in bone mechanics’. What it looks like, ways of measuring, what it does.- Manuel Doblaré (University of Zaragoza, Zaragoza, Spain)
1. Computational models for the prediction of Bone Fracture.
2. Damage-based phenomenological models of bone remodeling.
3. Mechanistic models of bone remodeling.
4. A biologically-based model of bone fracture healing.
5. Mechanical effects in bone fracture healing.
6. Computational methods in the design of bone prostheses and implants.
7. Thursday, Q&A- Alicia J. El Haj (Keele University Medical School, Stoke-on-Trent, Great Britain)
1. Bone cell biology.
2. Differentiation of bone cells and the bone cell lineage.
3. Bone development and remodelling.
4. Mechanotransduction and bone cell signalling.
5. Controlling bone cells by physical forces/Applied cell biomechanics.
6. Bone cell apoptosis and cell turnover.
7. Wednesday Q&A- Allen E. Goodship (Univ. College & Royal Veter. College, Stanmore, Great Britain)
1. Bone modeling and remodeling.
2. The dynamics of mechanically related remodeling.
3. Functional adaptation in bone tissue.
4. Mechanically related responses in bone cells.
5. Mechanically related responses in bone cells (con’t).
6. Practical applications, osteoporosis, implant design.
7. Tuesday Q&A- Bert Van Rietbergen (Eindhoven Univ. of Technology, Eindhoven, The Netherlands)
1. Trabecular bone imaging and modeling.
2. The mechanical optimality of bone structures and osteoporosis.
3. Regulation models for strain-adaptive remodeling at the trabecular level.